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Dechallenge and Rechallenge in Drug Side Effects: How Doctors Confirm If a Medication Caused an Adverse Reaction
  • Dec 30, 2025
  • Posted by Cillian Osterfield

Dechallenge and Rechallenge in Drug Side Effects: How Doctors Confirm If a Medication Caused an Adverse Reaction

Dechallenge and rechallenge are clinical methods used to confirm if a drug caused an adverse reaction. Stopping the drug (dechallenge) and, if safe, restarting it (rechallenge) provide the strongest evidence of causality in pharmacovigilance.

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