Fatigue: Causes, Links to Medications, and What You Can Do

When you can’t shake off exhaustion no matter how much you sleep, you’re not just tired—you might be dealing with fatigue, a persistent lack of physical or mental energy that doesn’t improve with rest. Also known as chronic tiredness, it’s not a disease but a signal something else is off—like a medication side effect, an undiagnosed condition, or how your body handles stress. Unlike normal tiredness after a long day, this kind of fatigue sticks around for weeks or months, even when you’ve slept well, eaten right, and cut back on caffeine.

Fatigue often shows up alongside CNS depression, a slowdown in brain and nervous system activity caused by mixing drugs like sedatives, opioids, or alcohol. That’s why posts here cover how mixing painkillers with sleep aids can leave you drained, not just drowsy. It also links to medication side effects, how drugs like chloramphenicol, nitrofurantoin, or even domperidone can quietly sap your energy. You might not realize your antibiotic or heart medication is the real reason you’re dragging through the day. And it’s not just drugs—conditions like thyroid issues, diabetes, or autoimmune diseases (think lupus or rheumatoid arthritis) can trigger fatigue as a core symptom, often before anything else shows up.

What you’ll find here isn’t guesswork. These posts dig into real cases: why someone on azathioprine for lupus feels wiped out even as their flare improves, how dipyridamole helps diabetic patients stay energized by protecting blood vessels, or why taking trim Z for weight loss leaves some people exhausted instead of refreshed. You’ll see how fatigue connects to sleep disorders, anxiety, and even how smoking slowly drains your oxygen and stamina. No fluff. No vague advice. Just clear links between what you’re taking, what’s happening in your body, and why you feel so drained.

If you’ve been told it’s "just stress" or "you need to sleep more," but nothing changes, you’re not imagining it. The answers are in the details—and they’re right here.